If you have the M22's set the amp to small speakers and sub output to LFE only, I think most amp when set to small there is no option for LFE+Mains.

If you have M80/60's I perfer to set the Mains to 80hz the Centre "if" the VP150 to small, "if" the you have the VP180 set to large.
For the sub setting if running M60/80 I would set it to LFE+Mains
If you don't find it blends well cut it to LFE only and set the Mains to small

Anthem MRX520
M5HPv4
VP160HPv4
QS10v4