I have not heard M22s + sub so I can't comment on that. However what I can comment on is the crossover setting on the M80s. There is a significant difference in bass when crossing them at 80Hz vs 60Hz or 40Hz. Even though the sub handles the lower frequencies, the bass sounds different. I personally prefer them crossed at 60Hz and even 40Hz, specially for music. For me, the bass in the 40 to 80Hz range coming from the M80s has more punch/feel than the bass coming from the EP600. If M22s + sub sounds similar to M80s + sub,it would be when crossed at 80Hz or higher.
