Only Photoshop, probably not much.

I use CaptureOne, and until version 5 it was all CPU. But in 5 they added CUDA support. Even with my old 8800 GTS 512 it cut the raw processing time down from 5 seconds an image to less than 1 second.

Pioneer PDP-5020FD, Marantz SR6011
Axiom M5HP, VP160HP, QS8
Sony PS4, surround backs
-Chris