I use the Harmony 1100 because I have access to every function for all devices through the touch screen. My equip is in a different room and it's much easier to scroll through this screen when needed, than to run back and forth between 2 rooms.

The con to the 1100 is the touch screen doesn't last. My first one lasted a year. I'm about 6 months into my 2nd one.

Now after having said that, I wouldn't mind trying the Harmony One to see what I would think of it.