I don't have a M80 alone setup. Since I listen to a lot of movies and pipe organ on SACD, even the M80 need a sub for the deeper notes (mine are combined to the HUGE EP-800).

But for less bass-heavy listening, the M22s alone are actually not bad at all.

To make a long story short (too late!), I am on the side of M80+sub vs M22+sub. (M2s + sub is a surprisingly good option too).

See Mojo's signature