Do you have a picture of the stand or something similar to help visualize? Will the sound be impacted vs a direct, unblocked setup? Yes, will it be terrible? Don't know, honestly, but the picture would be helpful to see how much bulk is there.
As a positive note, this is potentially more "doable" with a sub vs. with a regular speaker, so at least that is going for you.
The EP350 is front firing, so you generally want that as unobstructed as possible.
2-M60s, VP180, 8-M3s, SVS 20-39PCi, DIY Sub, 8-Shakers, JVC RS45, Anthem MRX-1120