Hello repeddler,
Using the asymmetrical placement scheme for your surrounds, you should definitely get the quadpolar-radiating QS4s. They'll generate a sense of envelopment in the soundfield with greater ease and less "fussiness" in positioning than direct radiators like the M2s or M3s.
I presume you're using a subwoofer with the M22ti's? You have a fairly big room, and while the M22's have reasonable bass output to 50 Hz or a bit lower, they do need the bass reiniforcement for the bottom octave that a subwoofer will deliver.
Regards,
