Hi,
Oh, absolutely, you'll want to use the sub playing music with the M22ti's as well as with home theater. While the M22's bass is quite good to 50 Hz and below, and they'll play cleanly with clarity at loud levels, in a room the size of yours, the sub will add the bottom octave of deep bass and relieve the woofers in the M22ti of deep bass duties. This will leave them free to do a gorgeous job on the upper bass and midrange (upper bass meaning from 80 Hz up to 800 Hz), where they excel.
Regards,
