I have M80's with 2 subs crossed at 80 hz and i am quite happy though i may be looking at making a couple mid bass modules, im a bass glutton. Either would be good , though in your size room if you can swing it i would go M100 . The VP160 imho is a more conventional design for a sub so it would be my choice. Its deeper than the vp180 but not as wide.

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M80 V3 MY GLOSS Cherry