Did,
I am using The Harmony hub( NO REMOTE) just the hub running thought a mac mini work awesome. I have been using assorted Harmony remotes for 15 years. I have no need for the remotes unless I have some issue that is rare. Everything runs Thought the harmony.
RJ

M100 V4, VP180 V4,QS10s x4 V4 M2 V4 X2 EP500 V4 X 2,ADA 1500-3, ADA1250 - 7 N3