I have the M22s with a cheap sub for my HT and music/ht is about 60/40. Actually, the music listening went UP after I got them. They are that amazing. They have (in my opinion) amazing mid-range and clarity (read that as neutral) and will probably fit your needs. I will someday get a much better subwoofer, but not until I move out of an apartment building.
The main concern I would have is not if the M22s would sound good, but if you need larger speakers for your space. It's always recommended and encouraged that you call Axiom and ask what speakers they would recommend. I have read on these boards that they talked people OUT Of M80s. To me that means they want happy customers not just more money.

jr


"What can be asserted without evidence can also be dismissed without evidence." C Hitchens