You'll have to play with it a bit, but you should see some benefit. Bearing in mind that I haven't heard the Hsu or the EP350, you should probably also consider SVS and Hsu subs in the same price range. Now, if you're looking at ~$11-1200 for a sub, go with the 500, hands down. 400 if you want a smaller box, although I have yet to see a review of one.

I am the Doctor, and THIS... is my SPOON!