>>The M22 I currently have do a great job, maybe I will only go to the M60's. What about the sub? Is 500 to large should I only go to a 350?>>
Have you considered wall mounting your M22s? You can get the Axiom wall brackets and just mount them on a stud. For your room size, if you get an EP500 sub it will produce clean low bass, lower and cleaner and more musical than the EP350.
If you can swing the M22s wall mounted, i would go with that option and pick up an EP500 sub, this will literally be more than enough for your room size.
If you can't wall mount your M22s, the M60s will be a fine choice.
