I don't have a receiver with Audyssey yet, so can't help much on using it, yet. \:\) Depending on what your other speakers are in the setup, you may be able to get away with setting the mains to large to help with the low end, but most often small is the best setting.

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85