In my experience M22/sub is pretty close in sound quality to M80 and the M60s are not far behind, but as you are looking at the EP175 which doesn't reach as low as the EP350 and higher subs, I bet the M22/EP175 would sound very similar to M60s.
As JC mentioned, consider your size of room and more importantly the listening distance. The M60s will play louder than the M22s and this could be required for loud listening volumes if your room is large; also you would need about 18" of floor space for the M60s as they need to be at least ~2" away for the ports to breath properly.
