I agree completely with John. My EP350 is not as capable as his EP500 but it still gets me to ~20Hz and has a major impact with pipe organ music. In fact, that was one of the reasons I wanted a sub.
Unless you are both sitting far away from the speakers AND like to listen very loud, the M22 + sub will be an excellent combination.
I had the pleasure of comparing the M22 + sub directly to the M60 and was surprised at how close the two sounded: almost identical above the sub-bass region.
I think that the M80 has something extra to offer, but if it were a choice between the M80 and an M22 + capable sub, I would go with the M22 + sub.
