Other folks will chime in here but a couple of thoughts. That is a big room to fill. I think you really need to take a look at the 60s if not the 80s. How far back is the listening area? I don't think bookshelfs will cut it in that size of room. If you are looking for loud volume levels in that size of room, 80s would be the way to go. The HK 7300 is the flagship receiver in their line and is an excellent choice to pair with the 4ohm M80s if you choose to go that direction. You will need a sub for HT and probably a solid one in that size of room. For music listening a sub is not usually required with either the 60s or 80s, depending on specific listening tastes. I think the QS8s would be perfect for you. Just my $.02
Bigjohn beat me to it.
