I guess with a big amp and the bass turned up to +10 you could probably do some pretty good damage -- but again the bigger risk is driving the amp into clipping and frying a midrange or tweeter as a result. When you run in "small" the amp doesn't have to carry those low signals so less power is required, ie you can play louder without clipping...

M60ti, VP180, QS8, M2ti, EP500, PC-Plus 20-39
M5HP, M40ti, Sierra-1
LFR1100 active, ADA1500-4 and -8