I read a couple book recently that are very relevant to where this discussion is heading.The first is is fairly old but quite concise and a quick read. Author is E.F. Schumaker and the book is called A Guide for the Perplexed. It discusses science and religion and puts forward the strong thesis that human existence is more than Science alone can explain and enlighten.

The second book is by Joseph Campbell -- of comparative mythology fame. It's called Pathways to Bliss. It discusses the mature of modern life as being "pathless" and how it's important to find a kind of personal mythology to inform your life.

Neither of these would fall into the self-help category, by the way. ;\)