From what I have read here, M22s seems to be closer to M60s in sound than M50s. Since you are buying a sub to go with them, and considerding your room size, M22s would be fine. However, for 2 channel music listening without a sub, I would prefer floorstanders.

Axiom M60s, QS4s, VP100 Onkyo TX-SR804 Oppo 970HD Rotel RB-1080/RCD-1072 REL Q150E sub, PS 3