Dan, welcome. For the size of your room and the intended use the M22s would be excellent for mains. As both Skerdi(thyname) and John B. mentioned you can at least temporarily do without a center speaker and let the mains form a "phantom" center. After the mains, the surround speakers, especially for movies, should be the next priority, and QS4s should suit your room well. Having a sub would also be highly desirable. So far as power, your 801 should have more than you'd need and there'd be no good reason to consider a separate amplifier, which should only be seriously considered if you'd need several hundred watts per channel.
