The M22s are pretty amazing speakers if your space is tight. However, if you're considering the VP160, you'd be a lot better off matching that with M60s (assuming you have room for floor standing speakers). Add the QS8 surrounds and you'll have an excellent system in that size room.

I started out with nothing & I've still got most of it left
M60 VP160 QS8 EP350
M22 VP100