I should have been more clear. In my room, for music, an M80v2 pair without a sub is substantially better than an M22v2 pair with an EP600v2. Sub or no sub, the M22v2 sounded too thin and lacked presence compared to the M80v2. For movies, I could live with the M22 with a sub because I am less fussy about audio quality when it comes to movies.
I can't speak for the M100 because I've never heard it. However, my M80v2 pair, at any practical volume, is far better with my EP600v2 (and other subs I've tried) than without.
