On Brendo's point, I'll just throw in that you will hear a lot more detail with M5s compared to M3s. Better mid-range, lower and more linear bass, and more airy highs as well. The M5s need more power though due to the HP driver but that shouldn't be a problem for the 4500H.

House of the Rising Sone
Out in the mid or far field
Dedicated mid-woofers are over-rated