Charles,

Consider how far you need to sit away from the M22s in order to have a good sound-stage. When I had them at my place, they were spaced 8 feet apart and I was 8 feet away (ie. the golden triangle). I don't know how they would sound if they were say 3 feet apart and you were three feet away. Also, stands are likely an excellent idea. You'd hate to hear the M22s acoustically coupling to your desk. You should talk to someone at Axiom that is knowledgeable about all of this before you make such a move.

House of the Rising Sone
Out in the mid or far field
Dedicated mid-woofers are over-rated