With M22s, the mids will be thinner than M80s; they won't be as full and rich. Also if you like to turn it LOUD, they might not have enough 'nad mass. You'll also want to evaluate how far apart they can be placed before the imaging and soundstage collapses for your set-up.

House of the Rising Sone
Out in the mid or far field
Dedicated mid-woofers are over-rated