The first thing that came to my mind after reading the title was to go with only one midrange in the center, to give you a WTMTW configuration following the similar pattern of the VP180. Maybe to compensate for only one midrange, could you go with a larger size midrange than a 5.25"?

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85