Hiya Kurt. I'm very pleased with the VP100 in a 16x22x10 room. While I have the QS8s, I'd suggest the 4s would work well (and save some $$$) in a room your size. Same tweeter was mentioned above. Worst case is that you may play everything a db or two louder, but the audio quality will be excellent. Also, your fronts will help create a false center effect to supplement the VP100.

I hope momma is recovering nicely!

Ray