Second that. I really like the layout.
First and foremost -- that is a big honkin' room from a subwoofer's point of view. Definitely 60/500 over 80/350.
Second -- with open space on the left and window on the right, it's going to be a challenge getting good imaging. Any chance of rotating everything to the right by 90 degrees, so the speakers are flanking the window and the main listening chairs/couch act as a room divider between kitchen/dining and living room ?
If not, you're probably going to want to look at some heavy drapes for the window to try and match the open area on the left.
EDIT -- looks like I wasn't the first to suggest rotating the room
