Hey Mark, we need to get out the lassos and round this M50 posse up
I can't speak for the M22's, but I have heard they are fabulous speakers. I also have the Denon 2805 and my M60's sound freaking unbelievable. I'm sure the sound stage, detail, transparency, etc. would be just fine, if not better. Not sure what your room conditions are, as the M60's will be bigger, but they aren't over bearing.
ps: I stay up at night wondering if I should have got the M80's
Mansfield Beech m60's vp150 ep350 4-qs8's
Denon 2805
Sanyo PLV-Z2 WXGA projector
Toshiba P.S. DVD Player
Samsung OTA HD receiver