I've had both. The M22 plus sub is very nice sounding. It's probably better than 90% of what people have heard.
However the M60s are better. They have a fuller soundstage and more midrange presence.
I was so happy with my M22s if I had to stick with them I'd be happy. However I dropped plans for a fancy custom console, giving me room for M60s.
Don't worry about your M22s. They are fantastic sounding speakers.
Get some SACD or DVD-A surround music and enjoy the speakers you have.
OTOH if money and space are no problem, you don't lose anything with the M60 but space and dollars.