I've had the Harmony One for about a month now and I absolutely love it. I'm still tweaking the settings, so it just keeps getting better. Even my wife took the transition well. So far, I only have one small complaint. The bottom is too rounded, so when it's sitting on the coffee table I can't work it just by pressing the buttons without having to pick it up. Minor, but annoying.

I started out with nothing & I've still got most of it left
M60 VP160 QS8 EP350
M22 VP100
Algonquins